Respiratory Clinical Research


WCCT Global sets the bar for respiratory Clinical Research Studies.

Allergen bronchial challenges

Is used to detect allergic asthma at times when no symptoms are present. It can diagnose occupational asthma when the allergen is unknown; can evaluate response to workplace allergens. If allergic asthma is present, exposure to the allergen will cause constriction of the bronchial tubes. The resulting decrease in lung function can be measured with a spirometer.

Bronchoscopy with BAL

A bronchoscopy is a diagnostic procedure in which a tube with a tiny camera on the end is inserted through the nose or mouth into the lungs. The procedure provides a view of the airways of the lung and allows doctors to collect lung fluids. Bronchoalveolar Lavage (BAL) uses salt water saline to flush the area and collect cells to be analyzed. BAL is performed to obtain a sample of the cells, fluids, and other materials present in the very small alveoli (air sacs).

Methacholine Challenge

A methacholine challenge is a test to determine if you have asthma. It is performed by inhaling a medication (methacholine) in increasing doses in an attempt to produce a change in your pulmonary function test results.

Nasal challenges and lavages

The nasal challenge test is for confirming/excluding allergic rhinitis and causative allergens and involves applying a small amount of allergen solution directly to the nares.

Nasal lavage is a noninvasive method of obtaining inflammatory exudates following nasal allergen challenge (NAC), and permits cells and released mediators to be evaluated.

Nitric Oxide

An exhaled nitric oxide test is a specialized tests that can be used to check for asthma. A nitric oxide test involves breathing into a mouthpiece attached to a machine that can measure the level of nitric oxide in your breath. Nitric oxide gas is produced by the body normally, but high levels in your breath can mean your airways are inflamed — a possible sign of asthma.

Pulmonary Function Tests

Pulmonary function tests are a group of tests that measure how well the lungs take in and release air and how well they move gases such as oxygen from the atmosphere into the body’s circulation.

Sputum Induction

Sputum induction is used to obtain sputum for diagnostic purposes. The procedure uses sterile water or hypertonic saline to irritate the airway, increase secretions, promote coughing, and produce a specimen.

 The atmosphere of Earth is the layer of gases surrounding the planet Earth that is retained by Earth’s gravity. The atmosphere protectslife on Earth by absorbing ultraviolet solar radiation, warming the surface through heat retention (greenhouse effect), and reducingtemperature extremes between day and night (the diurnal temperature variation).
Chronic obstructive pulmonary disease (COPD), also known as chronic obstructive lung disease (COLD), and chronic obstructive airway disease (COAD), among others, is a type of obstructive lung disease characterized by chronically poor airflow. It typically worsens over time. The main symptoms include shortness of breath, cough, and sputum production.[1] Most people withchronic bronchitis have COPD.
Exercise-induced asthma, or E.I.A., occurs when the airways narrow as a result of exercise. The preferred term for this condition isexercise-induced bronchoconstriction (EIB); exercise does not cause asthma, but is frequently an asthma trigger.