Although much has been discovered about the immune system, researchers are still exploring how invading microbes, infected cells, and tumors are targeted while the healthy tissues are left alone.
The genetic component that direct the human immune response, as well as those that dictate the biology of viruses, bacteria, fungi, and parasites is gradually being deciphered. New technologies and a growing knowledge of genetic information will reveal more about how the body guards itself from infection and disease.
The WCCT Global research unit strives to be on the forefront in the clinical development of new therapies for the prevention and treatment of infectious and immune-mediated diseases. New vaccines, delivery systems, treatments and antimicrobial agents are necessary to combat the ever-evolving threats to human health.
Peripheral Blood Mononuclear Cells:
Current research in the fields of immunology, hematology, infectious diseases, vaccine development, and transplant immunology requires the use of peripheral blood mononuclear cells (PBMCs). These blood cells (i.e. lymphocytes, monocytes, or macrophages) are a critical component in the immune system to fight infection. These cells ability to determine the difference between the body’s own cells and to adapt when the presence of foreign intruders is detected, contributes to a healthy immune system.
WCCT Global’s research units are capable of harvesting and preserving PBMCs for further research utilizing the Ficoll method. Cells can be stabilized and kept refrigerated for immediate use or stored frozen for future analysis.
|mononuclear cells pbmc||A peripheral blood mononuclear cell (PBMC) is any peripheral blood cell having a round nucleus. These cells consist of lymphocytes (T cells, B cells, NK cells) andmonocytes, whereas erythrocytes and platelets have no nuclei, and neutrophils, basophils, and eosinophils have multi-lobed nuclei.|
|antigen presenting cells||An antigen-presenting cell (APC) or accessory cell is a cell that displays foreign antigens complexed with major histocompatibility complexes (MHCs) on their surfaces; this process is known as antigen presentation. T-cells may recognize these complexes using their T-cell receptors (TCRs). These cells process antigens and present them to T-cells.|
|information nondiscrimination act||The Genetic Information Nondiscrimination Act of 2008 , enacted May 21, 2008,GINA, pronounced Gee-na), is an Act of Congress in the United States designed to prohibit the use of genetic information in health insurance and employment. The Act prohibits group health plans and health insurers from denying coverage to a healthy individual or charging that person higher premiums based solely on a genetic predisposition to developing a disease in the future. The legislation also bars employers from using individuals’ genetic information when making hiring, firing, job placement, or promotion decisions. Senator Ted Kennedy called it the “first major new civil rights bill of the new century.|
|human peripheral blood||Peripheral blood cells are the cellular components of blood, consisting of red blood cells (erythrocytes), white blood cells (leucocytes), and platelets, which are found within the circulating pool of blood and not sequestered within the lymphatic system, spleen, liver, or bone marrow.|
|The effects of global warming include effects on human health. This article describes some of those effects on individuals and populations. The observed and projected increased frequency and severity of climate related impacts will further exacerbate the effects on human health.|